The First 1000 Days of Life and the Risk of Future Drug Consumption

Context: The first 1000 days of life last from the beginning pregnancy to age two, a unique step that shapes basis for person’s health over their lifetime. Numerous studies have indicated relationship between one’s and consequent adverse outcomes in adulthood. However, extent we reviewed it, not single study has shown various aspects an individual’s probability drug consumption adult life. Hence, primary purpose this narrative review was understand role on vulnerability abuse later Evidence Acquisition: This article is identified susceptibility substance articles were extracted valid databases, including PubMed, Scopus, Science Direct, Web Science, Embase. Results: Various significant research pointed mother’s distress anxiety during through embryonic planning, influencing planning hypothalamic-pituitary-adrenal (HPA) axis epigenetic changes. intestinal microbiota part complex link named microbiota-gut-brain can affect variety number microbiota. On other hand, function as chronic stress by affecting enteric nervous system (ENS), which activates concurrent HPA dopamine pathways changing reward circuit subsequent increase abuse. results factors, such exposure childhood experiences (ACEs), parental separation, attachment insecurity, Nevertheless, quality nurturing care warm with children may hinder addiction society. Conclusions: one's are crucial delicate stage. If these tainted unpleasant events, mechanisms reduce person's resilience How infant’s period, prenatal stress, use pregnancy, ACEs, maternal-infant bonding, maternal separation (MS), microbiota, future. As result, focusing critical adapting prevention strategies. Health policymakers design suitable entries early